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Transplanting the seedlings into lime histone deacetylase inhibitor containing soil resulted from the loss of most plants. Chia was identified to contain 17. 5 mol of tanshinone IIA per kg of root material.

The presence IEM 1754 of tanshinone IIA and similar compounds in chia could explain the historical use of this plant, to wake the dead, or the nearly dead such as with stroke and heart attack patients. Tanshinones have a range of pharmacological activities including inhibition of clotting, vasodilatation and inhibition of NO synthase. All of these activities are potentially beneficial in stroke. Stroke is frequently caused by blood clots that dislodge from one location and travel in the blood system until they lodge in small cerebral arteries. This causes brain ischemia and usually stimulates more clotting in the area. Vasodilatation and inhibition of clotting may help dislodge and dissolve the clot. NO synthase is known to become activated in ischemia and can generate NO that damages DNA leading to cell death.

Chia contains two times more active tanshinones than does dan shen. This implies that chia may be superior IEM 1754 to dan shen for use as a delivery agent or precursor for tanshinone IIA. It may be of interest to test dan shen and chia extracts to see which plant extract produces higher plasma levels of tanshinone IIA and better protection from infarction. The hepatocyte growth factor receptor c Met is a tyrosine kinase receptor with established oncogenic properties. Activation of c Met results in phosphorylation of the receptor that leads to the recruitment of adaptor proteins and to the subsequent activation of various signal transducers, including phosphatidylinositol 3 kinase and extracellular regulated kinase 1/2, resulting ultimately in the stimulation of growth, survival, motility, and invasion in certain cell types.

Three human EA derived cell lines have been previously described. A549 is a human derived non? small cell lung cancer cell line previously shown to be c Met ? responsive. Seg 1 was maintained in RPMI 1640 medium, and Bic 1, Flo 1, and A549 were maintained in DMEM.