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The extract was obtained from the dried root of danshen. Danshen extract tablet used in this research was made according towards the techniques with the Chinese Pharmacopoeia, which contained an extract of 1 g danshen manufactured by Shanghai Leiyong Shong Pharmaceutical Limited Corporation.

The Waters HPLC technique, employed for determination with the components of danshen, consisted of a 515 binary HPLC pump, a 717 plus Cabozantinib autosampler, a column incubator, a 2487 ultraviolet detector, and Breeze Software. A Lichrospher C18 column was used for analysis. For determination of hydrophilic components, the mobile phase was 0. 5% acetic acid:methanol. Elution was carried out at a ?ow rate of 1 ml min?1 and at a column temperature of 35 C. The detection wavelength was set to 282 nm. For determination Capecitabine of the lipophilic components, the mobile phase was 0. 5% acetic acid:methanol. The ?ow rate was 1. 0 ml min?1. The detection wavelength was set to 254 nm. The contents of the lipophilic components in each table found were: cryptotanshinone, tanshinone I and tanshinone IIA, the contents of the major hydrophilic components were: danshensu, protocatechuic acid and salvianolic acid B.

Twelve healthy subjects were randomly selected from a pool of healthy volunteers. The ethics committee of Yijishan Hospital, af?liated to Wannan Medical College, approved the clinical protocol and informed consent form. All subjects Capecitabine signed an informed consent form before the study. The study design was a sequential, open label, two period, cross over trial conducted at the Drug Clinical Research Organization of Yijishan Hospital. On the morning of day 1, after oral administration of a single dose of 100 mg theophylline, 4 ml blood samples were taken at 0, 0. 5, 1, 2, 3, 4, 5, 6, 8, 10, 12 and 24 h. On day 2, subjects received danshen extract tablets three times daily, four tablets each time for 14 days. On day 15, they received four danshen extract tablets together with 100 mg theophylline.

Only 10 ?l of supernatant was injected into the HPLC column. Safety and tolerability were evaluated through adverse events reported by the doctors and subjects. AEs were assessed by the doctors with regard to severity and relationship to study treatment.